Mechanisms of Vaccinia A36R in F-actin nucleation

Mechanisms of Vaccinia A36R in F-actin nucleation

Vaccinia A36R protein interacts with N-Wasp protein through Nck and Grb2 proteins. This interaction activates Arp2/Arp3 complex and F-actin nucleation.

Major types of stem cells

Major types of stem cells

Stem cells have been increasingly viewed as potential therapeutic modalities in several diseases. In this respect both embrional and adult stem cells showed therapeutic potential.

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Rb pro-apoptotic and anti-apoptotic function upon DNA damage

Rb pro-apoptotic and anti-apoptotic function upon DNA damage - link

Retinoblastoma protein can have both pro- and anti-apoptotic functions in DNA damage response, depending on the particular cell type and activation state.

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Stepwise EGFR-HER2 activation & phosphorylation

Stepwise EGFR-HER2 activation and phosphorylation - link

EGFR-HER2 receptor complex is an important trigger of the oncogenic process. The process of tyrosine phosphorylation upon receptor activation undergoes a sequence of molecular steps that ultimately lead to signal transduction in cancer.

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Rb acetylation in DNA damage response

Rb acetylation in DNA damage response - link

Retinoblastoma protein is acetylated by p300 protein acetylase and deacetylated by HDAC and SIRT1. Acetylation causes Rb activation and E2F sequestration and deacetylation reverses this process.

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Signaling Pathways

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Signal Transduction - Wikipedia resource

Wnt Signaling Pathway - Wikipedia resource

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Ras regulators

Ras regulators - link

Ras oncogene is regulated by GTP binding and GTP hydrolysis, which is associated with Ras-dependent signal transduction. Several factors affect Ras GTP binding and hydrolysis, including T-cell receptors, GPCR receptors, Growth factors and calcium.

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