Stepwise EGFR-HER2 activation & phosphorylation

Stepwise EGFR-HER2 activation and phosphorylation - link

EGFR-HER2 receptor complex is an important trigger of the oncogenic process. The process of tyrosine phosphorylation upon receptor activation undergoes a sequence of molecular steps that ultimately lead to signal transduction in cancer.

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Rb acetylation in DNA damage response

Rb acetylation in DNA damage response - link

Retinoblastoma protein is acetylated by p300 protein acetylase and deacetylated by HDAC and SIRT1. Acetylation causes Rb activation and E2F sequestration and deacetylation reverses this process.

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Signaling Pathways

Signaling Pathways links:

Signaling Pathways - links to PowerPoint slides

Signal Transduction - Wikipedia resource

Wnt Signaling Pathway - Wikipedia resource

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Ras regulators

Ras regulators - link

Ras oncogene is regulated by GTP binding and GTP hydrolysis, which is associated with Ras-dependent signal transduction. Several factors affect Ras GTP binding and hydrolysis, including T-cell receptors, GPCR receptors, Growth factors and calcium.

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